I have both the E-M5 & E-M1 set to 6400. If you're looking for the cleanest images then maybe that is not for you, but a higher ISO shot is better than no shot at all for a number of occasions.I used to set iso 3200 for e-pm2. For e-m10, I think I may set to iso 4000.
What about you?
Is it safe to go iso 6400?