There's often discussion about how FF/APSC cameras are better at high ISO than m4/3s cameras, and I'm not disputing that in most cases that is fairly true; however, much depends on the end purposes of the images that you take. In my previous life as a news and sports photographer, shooting at anything above ISO1600 with my E-5 was not ideal and above that really a last resort. With my E-M1, I'm more than happy to shoot at ISO6400 any day and if I were still doing news and sports, would go to the max without hesitation. To illustrate this, and because I was a tad bored on a Saturday night, I did a test shot of my usual subject at ISO speeds from 6400 to max, to see what I could get. The following shots were taken with my 90-250mm (at 250mm) handheld, trying to focus on the right eye (our left), camera set to 'P' for professional, 8m from the subject, lit by one 9W LED downlight and taken after quite a few red wines and beers (IBIS is great). The RAW files have been converted using Instant JPG from RAW (because it's damn quick and easy, and produces pretty good results) and I've posted the 800 x 600mm conversions without any further adjustment. While these are the smaller sized conversions, the full sized ones look exactly the same and you could get any one of them published in any newspaper, any time, without question (were it a newspaper relevant shot). Just a point to note, Instant JPG to RAW only converts the files to a max of 3200 x 2400 for some reason (but whatever). 6400: 8000: 10000: 12800: 16000: 20000: 25600: And this is a crop from the 25600 (almost) full sized shot to show a somewhat close-up: Usable or not?